|
KMID : 0624620180510040182
|
|
BMB Reports
2018 Volume.51 No. 4 p.182 ~ p.187
|
|
|
Force-mediated proinvasive matrix remodeling driven by tumor-associated mesenchymal stem-like cells in glioblastoma
|
|
Lim Eun-Jung
Suh Yong-Joon
Kim Seung-Mo
Kang Seok-Gu
Lee Su-Jae
|
|
|
Abstract
|
|
|
|
In carcinoma, cancer-associated fibroblasts participate in force-mediated extracellular matrix (ECM) remodeling, consequently leading to invasion of cancer cells. Likewise, the ECM remodeling actively occurs in glioblastoma (GBM) and the consequent microenvironmental stiffness is strongly linked to migration behavior of GBM cells. However, in GBM the stromal cells responsible for force-mediated ECM remodeling remain unidentified. We show that tumor-associated mesenchymal stem-like cells (tMSLCs) provide a proinvasive matrix condition in GBM by force-mediated ECM remodeling. Importantly, CCL2-mediated Janus kinase 1 (JAK1) activation increased phosphorylation of myosin light chain 2 in tMSLCs and led to collagen assembly and actomyosin contractility. Collectively, our findings implicate tMSLCs as stromal cells providing force-mediated proinvasive ECM remodeling in the GBM microenvironment, and reminiscent of fibroblasts in carcinoma.
|
|
|
KEYWORD
|
|
|
Actomyosin contractility, Glioblastoma, Proinvasive extracellular matrix remodeling, Tumor-associated mesenchymal stem-like cells
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|